John M Whitelock Selected Research

perlecan

9/2020	A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials.
12/2019	CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan.
1/2019	Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan.
5/2018	Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion.
1/2018	The multifaceted roles of perlecan in fibrosis.
4/2016	Ablation of Perlecan Domain 1 Heparan Sulfate Reduces Progressive Cartilage Degradation, Synovitis, and Osteophyte Size in a Preclinical Model of Posttraumatic Osteoarthritis.
1/2015	Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.
4/2014	Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells.
1/2010	Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan.
10/2008	Diverse cell signaling events modulated by perlecan.

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John M Whitelock Research Topics

Disease

8	Neoplasms (Cancer) 01/2022 - 02/2004
7	Inflammation (Inflammations) 01/2018 - 07/2010
4	Atherosclerosis 01/2021 - 01/2010
3	Melanoma (Melanoma, Malignant) 01/2022 - 07/2014
3	Thrombosis (Thrombus) 11/2016 - 01/2002
2	Carcinoma (Carcinomatosis) 05/2018 - 01/2018
2	Fetal Growth Retardation (Intrauterine Growth Retardation) 07/2017 - 01/2017
2	Wounds and Injuries (Trauma) 01/2017 - 10/2011
2	Arthritis (Polyarthritis) 01/2015 - 04/2009
1	Ischemia 09/2020
1	Pancreatic Neoplasms (Pancreatic Cancer) 12/2019
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Ovarian Neoplasms (Ovarian Cancer) 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Pre-Eclampsia (Preeclampsia) 07/2017
1	Hemorrhage 07/2017
1	Colonic Neoplasms (Colon Cancer) 01/2017
1	Hypertrophy 05/2016
1	Osteophyte 04/2016
1	Osteoarthritis 04/2016
1	Synovitis 04/2016
1	Pathologic Processes 05/2013
1	Rheumatoid Arthritis 10/2012
1	Vascular System Injuries 01/2010
1	Joint Diseases (Joint Disease) 04/2009
1	Hyperplasia 02/2004

Drug/Important Bio-Agent (IBA)

11	perlecanIBA 09/2020 - 02/2004
5	Proteoglycans (Proteoglycan)IBA 01/2021 - 10/2008
5	Proteins (Proteins, Gene)FDA Link 05/2018 - 07/2010
4	ceric oxide (cerium dioxide)IBA 01/2022 - 11/2013
4	GlycosaminoglycansIBA 01/2021 - 05/2013
4	Heparin (Liquaemin)FDA LinkGeneric 01/2018 - 08/2012
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017 - 10/2008
3	lubricinIBA 01/2015 - 07/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2017
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 01/2017
2	Conditioned Culture MediaIBA 05/2018 - 07/2014
2	CollagenIBA 01/2018 - 01/2015
2	Heparitin Sulfate (Heparan Sulfate)IBA 01/2018 - 04/2016
2	ChitosanIBA 01/2017 - 10/2011
2	CarbohydratesIBA 11/2016 - 01/2015
2	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 04/2016 - 07/2014
2	Biomarkers (Surrogate Marker)IBA 01/2015 - 04/2009
2	Biological ProductsIBA 05/2013 - 04/2009
1	AntibodiesIBA 01/2022
1	Endothelial Growth FactorsIBA 01/2022
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2021
1	oxidized low density lipoproteinIBA 01/2021
1	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 01/2019
1	EnzymesIBA 01/2019
1	ChondroitinIBA 05/2018
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2018
1	Platelet Factor 4IBA 10/2017
1	Thrombin FDA Link 07/2017
1	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 07/2017
1	BiglycanIBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017
1	AnticoagulantsIBA 11/2016
1	Hormones (Hormone)IBA 05/2016
1	Transcription Factors (Transcription Factor)IBA 05/2016
1	ProteomeIBA 01/2015
1	Aggrecans (Aggrecan)IBA 01/2015
1	Cartilage Oligomeric Matrix ProteinIBA 01/2015
1	Trypsin InhibitorsIBA 01/2015
1	Glycoproteins (Glycoprotein)IBA 01/2015
1	Fibronectins (Fibronectin)IBA 01/2015
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 07/2014
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 07/2014
1	Laminin (Merosin)IBA 04/2014
1	Peroxynitrous Acid (Peroxynitrite)IBA 04/2014
1	Matrix Metalloproteinase 7 (Matrilysin)IBA 04/2014
1	Sulfates (Sulfates, Inorganic)IBA 10/2012
1	L-SelectinIBA 10/2012
1	FucoseIBA 10/2012
1	OligosaccharidesIBA 10/2012
1	HydrogelsIBA 08/2012
1	Oxidants (Oxidizing Agents)IBA 01/2010
1	Peroxidase (Myeloperoxidase)IBA 01/2010
1	hypobromous acidIBA 01/2010
1	Blood Proteins (Serum Proteins)IBA 01/2002

Therapy/Procedure

4	Therapeutics 01/2022 - 01/2018
1	Drug Therapy (Chemotherapy) 12/2019